About 20 million Americans currently have type 2 diabetes, three times more than in 1980. Diabetes is a major risk factor for stroke and heart attack, is the leading cause of new cases of blindness, and is the largest cause of the need for dialysis. Diabetes is also usually progressive, meaning that on the same medications and on the same diet and exercise regimen, the blood sugar of a patient with diabetes will slowly increase, necessitating constantly increasing amounts of medications.
So des...
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Aspirin for Cancer Prevention not Ready for Prime Time
Let’s imagine that we had a hunch that lighting incense at midnight contributes to weight loss, and we wanted to test that hunch. How would we do that? We would recruit lots of overweight adults and (with their permission) randomly assign them into two groups. The first group would receive a wakeup call every night at midnight and would then light some incense. The second group would still receive a wakeup call (so that the sleep deprivation itself is not a difference between the groups) and w...
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Epidemiology is Much Worse For You Than Red Meat
"Red meat is not bad for you. Now blue-green meat, that's bad for you!” -- Tommy Smothers
I generally try to avoid writing about meaningless studies that should be ignored. First, there are a lot of them. Second, I don’t want to attract more attention to them than they already get in the media. But sometimes a meaningless study seems to perfectly confirm what we already wanted to believe. Then a feedback loop of reader gullibility and media misunderstanding ...Clostridium difficile Infections on the Increase
In 2010 I predicted that Clostridium difficile (C. dif.) would become a household name. C. dif. is a bacterium that infects the colon causing severe, sometimes life-threatening, diarrhea. C. dif. infection is frequently a complication of antibiotic use. Antibiotics can kill the normal bacteria in the colon and establish an opportunity for C. dif. to proliferate. After a course of a...
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Doctor, Test Me for Everything
“Doctor, I really want to stay healthy and I just got a big promotion/had a baby/had a grandchild, so I really don’t want to end up with some horrible illness. Please test me for everything.”
Primary care doctors hear requests like this all the time. It’s an impossible request to fulfill because it assumes two premises that are usually false. It assumes that we have a test for all illnesses, and that being diagnosed early with a dreaded illness makes a difference.
Monday’s NY Times published <...
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